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Technical Newsletter

19 February 2013

pH independent bi-layer self-microemulsifying tablets (SMETs) of Candesartan cilexetil with Fujicalin® and Neusilin®


Candesartan cilexetil (CDC), an angiotensin II receptor antagonist is a prodrug which gets converted to active drug Candersartan during absorption from the gastrointestinal tract. The conventional CDC tablets have a significantly low bioavailability of approximately 14% after oral administration.

Self-microemulsifying drug delivery system (SMEDDS) approach is becoming a common practice to enhance oral bioavailability of poorly water soluble drugs. To produce tablets of SMEDDS and to have a desired dissolution profile is considered one of the most difficult tasks for a formulator. Through several publications and commercial products, Neusilin® and Fujicalin® have proved to be one of the best adsorbent carriers available in the industry today. In this newsletter, we summarized a recent study by Sohn et al. where a-pH-independent fast release bi-layer self-microemulsifying tablets (SMETs) of Candesartan cilexetil were prepared using Neusilin® and Fujicalin® as adsorbent carriers.

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