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Technical Newsletter

19 February 2013

pH independent bi-layer self-microemulsifying tablets (SMETs) of Candesartan cilexetil with Fujicalin® and Neusilin®

 

Candesartan cilexetil (CDC), an angiotensin II receptor antagonist is a prodrug which gets converted to active drug Candersartan during absorption from the gastrointestinal tract. The conventional CDC tablets have a significantly low bioavailability of approximately 14% after oral administration.

Self-microemulsifying drug delivery system (SMEDDS) approach is becoming a common practice to enhance oral bioavailability of poorly water soluble drugs. To produce tablets of SMEDDS and to have a desired dissolution profile is considered one of the most difficult tasks for a formulator. Through several publications and commercial products, Neusilin® and Fujicalin® have proved to be one of the best adsorbent carriers available in the industry today. In this newsletter, we summarized a recent study by Sohn et al. where a-pH-independent fast release bi-layer self-microemulsifying tablets (SMETs) of Candesartan cilexetil were prepared using Neusilin® and Fujicalin® as adsorbent carriers.


01 July 2011

Immediate release of lbuprofen from Fujicalin® based fast dissolving self emulsifying tablets

In this newsletter we present a study, carried out by College of Pharmacy, Korea, published in Drug development and industrial Pharmacy, 2011. Kang et al reported the immediate release self emulsifying tablet (IR-SET) of ibuprofen (IBU) with Fujicalin, which can replace the viscous and liquid SEDDS by free flowing powder.

 

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01 September 2010

Reduce friability and improve tablet performance during stability studies with a combination of Fujicalin® and Neusilin®

This issue of Fuji's newsletter presents preparation of high quality and high loadable tablet of acetaminophen with Fujicalin® in combination with Neusilin® UFL2.

 

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01 October 2009

Comparison of tabletting properties of Fujicalin® with other similar direct compression excipients

This issue of Fuji's newsletter presents preparation of acetaminophen tablets with Fujicalin® and comparison with other similar direct compression excipients.

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01 June 2009

Blending and Content Uniformity of Micronized Low Density Acetaminophen - Comparison of Fujicalin® with Other DCPA'S

This issue of Fuji's newsletter presents preparation of acetaminophen with Fujicalin® and comparison with other commercially available DCPA's.

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01 April 2009

Preparation of Vitamin E Tablets with Fujicalin® and Comparison with Other Commercially Available DCPA'S

This issue of Fuji's newsletter presents preparation of vitamin E tablets with Fujicalin® and comparison with other commercially available DCPA's.

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01 January 2009

Oil Adsorption Capacity of Fujicalin® and Other Commercially Available DCPA'S

This issue of Fuji's newsletter presents oil adsorption capacity of Fujicalin® and compare it with other available DCPA's.

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01 January 2008

Fujicalin® - Synthetic Dibasic Calcium Phosphate Anhydrous

Fujicalin® is anhydrous and spherically granulated to solve your problems with hydrolysable as well as oily actives. This is the second in series of the newsletters, where we highlight the oil adsorption capacity as well as tabletting with Fujicalin®, our unique DCPA.

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01 December 2007

Fujicalin® - Synthetic Dibasic Calcium Phosphate Anhydrous

Fujicalin® is a unique patented form of Dibasic Calcium Phosphate Anhydrous (DCPA). It is designed to function as a direct compression excipient and has exceptional flow and compression characteristics, while maintaining the ability for rapid disintegration.

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